Hi Damjan,
Thanks — that response tells us what's happening.
"Session mismatched." usually isn't a session problem. When you click Save, the page content and Joomla's security token go to the server in one request. If that request is too big for a server limit, PHP drops the whole thing — token included — and you get this message. The 500 comes from the same limit.
It fits what you're seeing: a new page saves, a small edit elsewhere saves, only this one large page fails.
Quick check (30 seconds): open the failing page, press F12 → Network, click Save, select the index.php?option=com_sppagebuilder request and note its payload size. Compare it with a page that saves fine. If the failing one is much bigger, that's the cause.
Fix 1 — cPanel → MultiPHP INI Editor:
post_max_size = 128M
memory_limit = 512M
max_input_vars = 10000
max_execution_time = 300
Fix 2 — your host. ModSecurity is a server module, not a Joomla extension, so it may be active even though you have no security extensions. Its default request limit is 128 KB. Ask your host to raise SecRequestBodyLimit, SecRequestBodyNoFilesLimit and LimitRequestBody, and to check the ModSecurity log at the moment you press Save.
Then clear all caches and retest.
One more thing: if you pasted an image directly into a Text/HTML addon on that page, replace it with a file from the Media Manager — that alone can make a page too large to save.
Let us know the payload size and we'll take it from there.
Best regards,